Ursolic acid

Name:Ursolic acid 
Specification: Ursolic acid（25-98%）HPLC 
CAS NO: 77-52-1 
Solubility: Good solubility in ethanol 
Color: White powder（Ursolic acid 98%）

EINECS: 201-034-0 

Chemistry: Ursolic acid [(3)-3-Hydroxyurs-12-en-28-oic acid] rarely occurs without its isomer oleanolic acid [(3)-3-Hydroxyolean-12-en-28-oic acid] They may occur in their free acid form, or as aglycones for triterpenoid saponins which are comprised of a triterpenoid aglycone linked to one or more sugar moieties. Ursolic and oleanolic acids are similar in pharmacological activity.

Molecular Formula : C₃₀H₄₈O₃ 
Molecular Weight: 456.71

Molecular Structure:

Melting point: 283-285 ºC 
Alpha: 59 º (c=0.3, pyridine) 
Synonyms: 3beta-Hydroxyurs-12-en-28-oic acid

Toxicity: Notwithstanding its numerous cosmetic properties, ursolic acid is an ideal cosmetic ingredient because its overall toxicity (both chronic and acute) is low. It is not a primary irritant or sensitizer. In fact, it has been termed dermatologically innocuous.

Storage: Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation

Shelf life: 2 year when properly stored

Packing: 25kg/ Drum or as customer’s request

Ursolic acid is a pentacyclic triterpene acid, used in cosmetics, that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor. 
Ursolic acid is also known as Prunol, Malol, Urson, beta-Ursolic acid, NSC4060, CCRIS 7123, CHEBI:9908, TOS-BB-0966, and 3beta-Hydroxyurs-12-en-28-oic acid. As medicine it is well tolerated and can be used topically and orally. 
Ursolic acid is present in many plants, including apples, basil, bilberries, cranberries, elder flower, peppermint, lavender, oregano, thyme, hawthorn, prunes.

PHARMACOLOGICAL ACTIVITIES 
Contemporary scientific research which led to the isolation and identification of ursolic acid revealed and confirmed that several pharmacological effects, such as antitumor, hepatoprotective, anti-inflammatory (oral and topical), anti-aging,,antiulcer, antimicrobial, anti-hyperlipidemic, sedation, antioxidation and antiviral, hair growth stimulant,can be attributed to ursolic acid which is widely used in medicine.It can inhibit Elastase. However, its anti-inflammatory (topical), antitumor (skin cancer), and antimicrobial properties make it useful in cosmetic applications.

How to take ursolic acid?

The only dose from which to work from is 10mg/kg bodyweight.

Note: Do not confuse with usnic acid