corosolic acid

corosolic acid

Banaba Leaf P. E.1%-98% Corosolic Acid 
Product Specification : 1%,10%,20%,98% Corosolic Acid

Cas No:4547-24-4
Latin Name: Lagerstroemia speciosa L

Product Type: Fine green powdered extract 
Part of the Plant Used: leaf

Molecular Formula: C₃₀H₄₈O₄

Molecular Mass: 456.68

Product attributes: White or beige powder, odorless, tasteless.

Extract Method: Water/ Grain Alcohol

HPLC Conditions: C18 analytical column:250 5.0mm, mobile phase: methanol/0.1%acetic acid (88/12, V/V), isocratic elution , flow rate: 1.0 ml/min, UV detection at 210 nm.

Product Packing: 25kg/drum with inner double- plastic bags. (0.065m³/drum)

Storage: In cool & dry place, keep away from strong light and heat.

Toxicology: A single oral dose toxicity study in rats administered Glucosol 5 g/kg showed no marked pathological findings.But toxicologic information regarding use in humans is lacking.

Dosage: Numerous commercial formulations are available, including tablets, capsules, hypoglycemic food products, and cosmetics. Most formulations are available in capsule form containing 18% corosolic acid extracted from L. speciosa . The manufacturer suggested dosage is 1 softgel by mouth 30 minutes before morning and evening meals. Softgel products are marketed for noninsulin dependent type 2 diabetic patients.

Application:

1、Be available in American as food additive.

2、Be used in dietary supplements as a glucose-lowering agent and insulin mimetic.

1、Avoid use with hypersensitivity to any of the plant sources of corosolic acid.

2、Avoid use in the pregnancy the lactation.

Corosolic Acid Interactions:Counsel patients with diabetes or those taking antidiabetic medications about potential additive effects if they are self-medicating with any oral corosolic dietary supplement.

What is Banaba Leaf extract? 
Banaba leaf extract contains a triterpenoid compound known as corosolic acid which has actions in stimulating glucose transport into cells. As such, banaba plays a role in regulating levels of blood sugar and insulin in the blood. For some people, fluctuations in blood sugar and insulin are related to appetite, hunger and various food cravings particularly craving for carbohydrates such as bread and sweets. By keeping blood sugar and insulin levels in check, banaba may be an effective supplement for promoting weight loss in certain individuals Banaba is a medicinal plant that grows in India, Southeast Asia and the Philippines. Traditional uses include brewing tea from the leaves as a treatment for diabetes and hyperglycemia (elevated blood sugar). The hypoglycemic (blood sugar lowering) effect of banaba leaf extract is similar to that of insulin which induces glucose transport from the blood into body cells. 
The blood sugar regulating properties of banaba have been demonstrated in cell culture, animal and human studies. In isolated cells, the active ingredient in banaba extract, corosolic acid, is known to stimulate glucose uptake. In diabetic mice, rats and rabbits, banaba feeding reduces elevated blood sugar and insulin levels to normal. In humans with type II diabetes, banaba extract, at a dose of 16-48mg per day for 4-8 weeks, has been shown to be effective in reducing blood sugar levels (5%-30% reduction) and maintaining tighter control of blood sugar fluctuations. An interesting (side-effect) of tighter control of blood sugar and insulin levels is a significant tendency of banaba to promote weight loss (an average of 2-4 lbs. per month) without significant dietary alterations. It is likely that modulation of glucose and insulin levels reduces total caloric intake somewhat and encourages moderate weight loss. 

Where will be Banaba Leaf extract used to? 
1、Antidiabetic

2、Anti-inflammatory

3、Antiproliferative

4、Protein kinase C inhibition activity

5、Help maintain low blood pressure and normal kidney function, preventing damage to blood vessels and kidneys

6、Help control appetite and cravings, helps promote weight loss

7、Reduce the tolerance of P. aeruginosa biofilm bacteria to antibiotics

8、Deliver a strong antioxidant activity to scavenge free radicals and to prevent cell membrane lipid peroxidation

9、May help with reaction to stress.

10、May help maintain cortisol levels within the normal range.