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Clomid Functions & Traits:
Clomiphene Citrate is a SERM that is specifically used as a fertility aid due to its ability to enhance the release of gonadotropins. Clomid has the ability to oppose the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis. This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) significantly. By increasing gonadotropin release, this can lead to the egg being released, thereby increasing the chance of conception.
Clomid also carries strong anti-estrogen properties that could be used therapeutically, but its anti-estrogen properties are most commonly associated with anabolic steroid use. Testosterone and many testosterone derived steroids have the ability to convert to estrogen through testosterone's interaction with the aromatase enzyme. As estrogen levels rise, this can lead to gynecomastia and excess water retention. Heavy water retention can also promote high blood pressure. By supplementing with Clomid during anabolic steroid use, the SERM will bind to the estrogen receptors, therefore inhibiting the estrogen hormone from binding. This can be very useful in combating gynecomastia, as when Clomid binds to the receptor it prevents estrogen from stimulating the mammary tissue. It can also have a positive impact on water retention, but as it won't actively reduce serum estrogen levels it's sometimes not enough.
Clomid also possess functioning traits that are beneficial to the anabolic steroid user post anabolic steroid use. Specifically we're referring to Post Cycle Therapy (PCT). In men, Clomid also has the ability to stimulate the pituitary to release more LH and FSH, which will in turn stimulate enhanced natural testosterone production. This is extremely beneficial to the anabolic steroid user post cycle as natural testosterone levels will be very low due to suppression caused by anabolic steroid use.
*Effects of Clomid:
In a therapeutic setting as a fertility aid, the effects of Clomid are simple. The woman is having difficulty becoming pregnant, Clomid enhances the chance of conception and pregnancy occurs. It doesn't always work and we'll look at the process in the administration section, but it will greatly increase the odds of conception and is fairly successful.
As an anti-estrogen for on cycle steroid use, Clomid is fairly effective at staving off gynecomastia. It will not reduce estrogen levels or inhibit the aromatization process, but in many cases, binding to the receptors is enough protection for many men. In fact, while there are stronger protective agents, many men would be surprised as to how well a SERM like Clomid can work if they would give it a chance. More
For many men, especially hardcore anabolic steroid users, Clomid is not enough for estrogenic protection. In this case, an Aromatase Inhibitor (AI) like Arimidex (Anastrozole) or Femara (Letrozole) will be needed. AI's actively inhibit the aromatase process and will see serum estrogen levels reduced. By far they are the most effective at combating gynecomastia and will have more success in combating water retention. In fact, SERM's like Clomid often do very little to combat water retention. However, in many cases, many performance athletes would do a better job controlling water retention if they did a better job controlling their diet. In off-season bulking plans this requires excess calories to grow. However, many take it too far, especially carbohydrate consumptions, and this will cause you to hold water with or without anabolic steroid use. Add in aromatizing steroids to the equation and water retention will be even greater. Further, AI's while effective will have a negative impact on cholesterol, which leads us to only one sane conclusion. Control your diet and if you can control gynecomastia with a SERM like Clomid it should be your first choice.
Then we're left with the effects of Clomid as they pertain to PCT. When we supplement with anabolic steroids, this will suppress natural testosterone production. The rate of suppression will be dependent on the steroids being used and to a degree the total dosing, but it will generally be substantial. For this reason, most men will always include exogenous testosterone in their steroid cycles. In fact, it's not uncommon for it to be the only steroid used. This will protect the individual from a low testosterone condition while on cycle. Unfortunately, once steroid use comes to an end natural testosterone levels will be very low. Natural testosterone production will begin again on its own, but it will take a significant amount of time for levels to reach their previous high state. In fact, total recovery can take months to even a year. Further, natural testosterone recovery is dependent on no prior low testosterone condition existing and assumes that no severe damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper anabolic steroid use.
Due to natural testosterone levels being low post cycle, most men are encouraged to implement a PCT program. This will stimulate natural testosterone production greatly and shorten the total recovery time. It will not return your levels to normal on its own; there is no PCT plan on earth that can do this. However, a solid PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise. Clomid is an excellent choice for this purpose and one of the most commonly used PCT medications. Highly successful PCT programs will often include Clomid and Nolvadex as well as the powerful peptide hormone (Human Chorionic Gonadotropin).
Those who forgo Clomid therapy post cycle or any type of PCT plan and are going to be off cycle for an extended period of time will rest in a low testosterone condition for an extended period of time. Not only is this an extremely unhealthy state, it can come with all the traditional low testosterone symptoms. Many will find cortisol levels greatly increase as testosterone levels are low, and as a result, body fat levels go up and strength and muscle mass decrease. If you're going to be off cycle for an extended period of time, 8 weeks or more there is no reason for forgoing a PCT program. If you are going to be off cycle for less than 8 weeks or bridging with a low dose of exogenous testosterone, which is very common in hardcore bodybuilding circles, this is the only time a PCT would be counterproductive.
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