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Somatostatin

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CAS: Somatostatin 
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Updated on: 2015-06-11
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Description

Apperancewhite to off-white, amorphous powder of low density
 
Solubility: Soluble in water at a concentration of ≥6 mg/ml to give a clear, colorless solution
 

Identity: Monoisotopic Mass: 1636.7 ±1 m.u.

(by Mass Special Analysis)
 

Identity                          

(by Mass Special Analysis)        

                  Asx   0.95 to 1.05

                  Thr  1.4 to 201

                  Ser   0.7 to 1.05

                  Gly   0.95 to 1.05

                  Ala   0.95 to 1.05

                  Cys   1.4 to 2.1*

                  Phe   2.85 to 3.15

                  Lys   1.9 to 2.1

                  Trp   0.3 to 1.1

*Hydrolyze without phenol to recover Cysteine
     
Identity:     
    Coelutes with reference standard
       System I (0.1% TFA/Acetonitrile)
       Gradient=20-45% in 25 minutes
       System II (0.1M TEAP, pH 2.3/Acetonitrile
       Gradient=20-45% in 25 minutes
 
Identity
(By TLC)
RF value of sample correspondes to reference standard
 
Peptide purity: 98%
By Analytical HPLC
 
Related substance ≤2% total, no single purity > 1%
 
Water (karl Fisher) ≤ 8%
Specific Rotation    -37o to -47o           [α]D~20 c=0.5, 1% acetic acid)
 
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