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Chem.Name: Phenanthro[1,2-b]furan-10,11-dione,6,7,8,9-tetrahydro-1,6,6-trimethyl
Molecular formula: C19H18O3.
Molecular weight: 294.33
CAS No: 568-72-9
Appearance: orange powder
【Pharmacology】 (1) on coronary artery function: coronary heart disease, can improve coronary circulation, inhibit thrombosis disease. Danshensu significant expansion of coronary artery, increase coronary blood flow, reducing myocardial oxygen consumption, slowing heart rate and increasing the role of myocardial contractility. Tanshinone Ⅱ A derived by sulfonation of a water-soluble substances tanshinone Ⅱ A sulfonate (Sodium Tanshinon Ⅱ A SilateA), can increase coronary blood flow, improve after hypoxia-induced myocardial metabolic disorders, thereby enhancing the ability of myocardial hypoxia tolerance. There are a significant role in protection of red cell membrane. Myocardial infarction in animals with reduced infarct size effect. There are certain doses enhance the role of myocardial contractility. They are relatively nontoxic. For coronary heart disease, chest tightness, and myocardial infarction, right ventricular premature beats may be used. Efficacy in patients with coronary heart disease with similar compound Danshen injection. (2) on cardiac repair: Danshensu and tanshinone IIA hypoxia can significantly prolong the time to reduce hypoxia-induced myocardial injury, while improving myocardial contractility and promote myocardial regeneration. (3) the role of micro-circulation: Danshen Shuxin capsule expansion of animal micro-arteries, so that the growing number of capillary networks and opening up, speed up blood flow, flow, thus improving microcirculation. (4) the role of blood rheology: Danshensu and tanshinone IIA can inhibit ADP-induced platelet aggregation, inhibition of platelet TXA2 synthesis and release of vasoconstrictor substances and the promotion of fibrin degradation. Can reduce coronary heart disease, cerebral ischemic stroke and myocardial infarction patients of the whole blood and plasma viscosity, reduced hematocrit, through the viscosity reducing the role of anticoagulant to blood rheology indicators back to normal. (5) The role of blood lipids: Danshensu inhibit the endogenous synthesis of cholesterol and reduce oxidized low-density lipoprotein (LDL) formation, reduce neutral fat can be used for hyperlipidemia induced atherosclerosis. (6) the formation of tanshinone Ⅱ A role against AS. Low density means the protein that causes bovine vascular endothelial cell injury protection. Increased blood cholesterol levels, especially in low-density finger protein (LDL)-cholesterol levels can cause increased arterial endothelial cell injury, resulting in the occurrence of atherosclerosis. The purpose of this study was to evaluate tanshinone Ⅱ A on LDL induced EC injury. Tanshinone Ⅱ A has anti-oxidation, can prevent LDL oxidation, thereby protecting EC, to maintain its normal function of secreting PGL2, anti-AS formation. (7), anti-infection, and surgery for purulent infections (acute tonsillitis, otitis externa, osteomyelitis, surgical infections, etc.). This product is one of Danshen antimicrobial active ingredient, in vitro inhibition test for human-type Mycobacterium tuberculosis H37 Rv bacteria have stronger activity. (8) for the treatment of cervical erosion. (9) the treatment of certain skin and acne. (10) in the treatment hepatitis and leprosy.
