Neohesperidin

Synonyms: NSC 31048;Neohesperdin;NEOHESPERIDIN;NEOHESPERIDIN (PR);(2S)-Neohesperidin;NEOHESPERIDIN WITH HPLC;HESPERETIN-7-NEOHESPERIDOSIDE;HESPERETIN-7-O-NEOHESPERIDOSIDE;HESPERETIN-7-NEOHESPERIDOSIDE hplc;rhamnopyranosyl-(1→2)-β-D-glucopyranoside

CAS Number: 13241-33-3

Molecular Weight: 610.56

Molecular Formula: C₂₈H₃₄O₁₅

Physical Appearance: Off-white to yellow to beige powder

product specification：95-98% main(HPLC)

CBNumber: CB6291569

MOL File: 13241-33-3.mol

Neohesperidin Property

mp : 239-243°C

storage temp. : 2-8°C

Appearance: Hoar  powder

CAS DataBase Reference: 13241-33-3(CAS DataBase Reference)

Safety

Safety Statements : 22-24/25

WGK Germany : 3

RTECS :DJ2981400

Description

Flavanone glycoside with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model.

For Research Use Only

Reference Numbers

PubChem Compound ID: 442439

References

1. Miller, E.G. et al., Inhibition of oral carcinogenesis by citrus flavonoids. Nutr. Cancer 60, 69-74, (2008) 2. Hwang, S.L. and Yen, G.C., Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. J. Agric. Food Chem. 56, 859-864, (2008);

Neohesperidin is one kind of isoflavones and has the function of depressing the blood pressure,depressing body temperature, increasing resistance of oxygen lacking, enhancing flux of coronary artery and etc.. The Neohesperidin Dihydrochalcone is a natural sweetener and contains low calorie. It is fit for obesity and diabetic. Depress blood pressure Like other isoflavones, neohesperidin has the function of depressing blood pressure. By restraining the brittleness of capillary vessel, Neohesperidin can effectively control the blood pressure. It also has the function to resist oxygen lacking and enhance flux of coronary artery. Natural sweetener Neohesperidin Dihydrochalcone (NHDC) is an intense sweetener which is several hundred times sweeter than sucrose at the applied concentration. Currently, Neohesperidin DC (NHDC) is authorized for human consumption, either as a sweetener or as a flavour modifier. For the low calorie and good taste, Neohesperidin Dihydrochalcone can be widely used in obesity and diabetic..

Neohesperidin Dihydrochalcone

Other names:
Neo-DHC

Taste:
Neohesperidin dihydrochalcone is up to 1000 times as sweet as sucrose, but it has a number of other properties that limit its use as a sweetener.  First, it has an intense cooling effect on the tongue.  Second, it has licorice-like and bitter off-tastes.  Third, it is slow in onset and has a lingering taste that make it decidedly not sucrose-like.  
     The concentration vs. response relationship in water is shown below (results in food systems will vary). This graph is based on data from DuBois, Walters, Schiffman, Warwick, Booth, Pecore, Gibes, Carr & Brands in "Sweeteners: Discovery, Molecular Design, and Chemoreception," D.E. Walters et al., Eds., American Chemical Society, 1991.  The units of R are percent sucrose equivalent; the units of C are parts per million (ppm).

      Neohesperidin dihydrochalconed functions to mask bitter taste in citrus, and it can enhance the sweetness of other sweeteners.  It has also been used to mask bitterness in pharmaceuticals.

Calories:
Neohesperidin is non-caloric.

Safety:
Neo-DHC has been approved as a sweetener by the European Union, but not by the FDA.  

Chemistry:
Neohesperidin dihydrochalcone (Neo-DHC)  is synthesized by chemical treatment of neohesperidin, a bitter component of bitter orange, grapefruit, and other citrus fruit peel and pulp.