Hesperidin

Synonyms: Cirantin, Hesperidine, Hesperidoside, Hesper bitabs, Hesperetin-rutinosid, Hesperidin, (2S)-, Hesperetin 7-rutinoside, USAF CF-3,Hesperetin 7-rhamnoglucoside,

What is Hesperidin?

Hesperidin is a flavanone glycoside consisting of the flavone hesperitin bound to the disaccharide rutinose. The sugar cause hesperidin to be more soluble than hesperitin.

Hesperidin is a flavanone glycoside found abundantly in citrus fruits. It is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. ^[1] In human nutrition, it contributes to the integrity of the blood vessels. Various preliminary studies reveal novel pharmaceutical properties. It reduced cholesterol and blood pressure in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects. It is also a potential sedative, possibly acting through opioid or adenosine receptors

Distribution

The phytochemical hesperidin is mainly found in citrus fruits such as lemons and oranges. The highest concentration of hesperidin can be found in the white parts and pulps of the citrus peels. Hesperidin can also be found in green vegetables.

Uses for Hesperidin

Hesperidin is thought to have beneficial effects on the blood vessels. Its touted as a natural remedy for a number of health problems, including:

·                         allergies

·                         hemorrhoids

·                         high blood pressure

·                         menopausal symptoms

·                         premenstrual syndrome

·                         varicose veins

Hesperidin is also said to improve circulation, reduce inflammation, and help prevent cancer

Hesperidin has antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions. Hesperdin can inhibit following enzymes: phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase. 

Hesperidin improves the health of capillaries by reducing the capillary permeability.

Hesperidin is used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti-cancer activity of hesperidin could be explained by the inhibition of polyamine synthesis. 

A study Hesperidin, a citrus flavonoids, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice by Hiroshige Chiba et al (J. Nutrition, June 2003) showed that hesperidin added to the died not only lowered serum and hepatic cholesterol, but also inhibited bone loss by decreasing osteoclast number in ovariectomized mice. The molecular mechanism of the inhibitory effect of hesperidin on bone resorption is not clear.

Is Hesperidin Safe?

Hesperidin is likely safe when used orally for less than a year. However, it may be unsafe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, its important to consult your physician if youre considering using hesperidin in combination with other medications.

In addition, hesperidin may be unsafe for people with blood disorders.

Hesperidin Side Effects

Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, and nausea.