Panax notoginseng saponins (PNS)

Specification: 98%,95%,80%,40%

The Chinese medicinal herb, Panax notoginseng, has long been used to treat bone fractures and Panax notoginseng saponins (PNS) could promote bone formation. Here, we investigated whether PNS could promote osteogenesis of bone marrow stromal cells (BMSCs) through modulating the MAPK signaling pathways, which are implicated in BMSC osteogenesis. We found that PNS markedly increased the mineralization of BMSCs by alizarin red S assays and stimulate alkaline phosphatase activity of these cells. Additionally, PNS significantly increased the mRNA levels of alkaline phosphatase, core-binding factor a1, and bone sialoprotein while decreasing PPARγ2 mRNA levels. Furthermore, inhibitors of ERK, PD98059, and p38, SB203580 inhibited the osteogenesis-potentiating effects by PNS. PNS stimulated the activation of ERK and p38 as evidenced by increased phosphorylation of these proteins, which was inhibited by PD98059 and SB203580. Our findings indicate that PNS could promote BMSC osteogenesis by activating the ERK and p38 signaling pathways.

PNS  could  protect  myocardial  cells  from  apoptosis  induced by ischemia in both the in vitro and in vivo models through activating PI3K/Akt  signaling  pathway.

1. About the Product:  Sanchi Extract 

  High Quality Sanchi Extract Notoginsenosides 80%  

Product Name:         Sanchi Extract 
Botanical Name:       Panax Notoginseng (Burk.)F.H.Chen 
Active Ingredients: Notoginsenosides   
Assay:                       Notoginsenosides 80%   
Test Method:           HPLC

Part of Plant Used:  Root 
Appearance:            Light Yellow Powder

Odor:                        Characteristic

CAS No.:                   88105-29-7  

2. Detail Information of Sanchi Extract 

  High Quality Sanchi Extract Notoginsenosides 80% 

 Physical & Chemical properties:

 1) Bitter taste
2) Soluble in methanol and water
3) Insoluble in acetone, ethyl-ether and benzene
4) Easy to absorb moisture

 3. Main function of  Sanchi Extract 

  High Quality Sanchi Extract Notoginsenosides 80%  

1) Sanchi Extract: Expand blood vessel, degrade blood pressureincerase blood flowprotect and cure heart brain tissue

ischemiarmalhypoxia
2) Sanchi Extract: Promote synthetizing of protein RNA DNA, make humanbody healthy
3) Sanchi Extract: Promote blood cell metabolism, balance and accommodate blood cell Central nerve two-ways regulation, brain

increasement, enhance study and remember ability
4) Sanchi Extract: Intensify organism immune function, anti-tumor, anti-aging
5) Sanchi Extract: Haemostasis activating blood circulation to dissipate blood stasis
6) Sanchi Extract: Liver protection anti inflammatory
7) Sanchi Extract: Blood sugar two-ways regulation degrade blood fatchole stangiosclerosis inhibition.

4. Main application of Sanchi Extract 

  High Quality Sanchi Extract Notoginsenosides 80%  

1) Sanchi Extract: Pharmacology
     Inhibition of the central nervous system
     Analgesic effect
     Hypolipidemic
     Antiarrhythmic

2) Sanchi Extract: Cosmetic
     Skin protection against UV & Ant ageing effect

3) Sanchi Extract: Food
     Anti-aging
     Improve sleep, soothe the nerves

5. Packing&Storage of Sanchi Extract

  High Quality Sanchi Extract Notoginsenosides 80%

Package:25kgs/drum,double plastic-bag inside, aluminum foil bag or fiber drum outside.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Shelf Life:Two years when properly stored.