Limonin

Other name

limonoate D-ring-lactone,limonoic acid di-delta-lactone

CAS number   ：1180-71-8

PubChem       ：179651

ChemSpider：156367

ChEBI     CHEBI:16226

ChEMBL CHEMBL：517449

Limonin is a limonoid, and a bitter, white, crystalline substance found in citrus and other plants. It is also known as limonoate D-ring-lactone and limonoic acid di-delta-lactone. Chemically, it is a member of the class of compounds known as furanolactones.

Limonin is enriched in citrus fruits and is often found at higher concentrations in seeds, for example orange and lemon seeds. Limonin is also present in plants such as those of the Dictamnus genus

Limonin and other limonoid compounds contribute to the bitter tasteof some citrus food products. Researchers have proposed removal of limonoids from orange juice and other products (known as "debittering") through the use of polymeric films.

Ongoing research programs are examining the effects of limonin in human diseases. Citrus seed extracts reportedly have antiviral properties, inhibiting replication of retroviruses like HIV-1 andHTLV-I.^[3] Neuroprotective effects of limonin have also been described.^[1] Limonin reduces proliferation of colon cancer cells^[4]and has been tested as an anti-obesity agent in mice