Cryptotanshinone

Synonyms : (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

Molecular Formula:  C19H20O3

Molecular Weight:  296.36

CAS Registry Number:  35825-57-1

Product Appearance: brick red needle crystal

Solubility:Soluble to 10 mM in DMSO

Genesal source: Salvia miltiorrhiza Bge.

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimers disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μ) and reduction in Aβ peptide generation.