10-hydroxycamptothecin

Synonym: Spyrano[3, 4: 6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione

Molecular Formula: C20H16N2O5

Formula Weight: 364.35

CAS No. 19685-09-7 ，7689-03-4

Botanical source: Camptotheca acuminata Decne

Appearance: Light Yellow Crystal Powder

Odor: Characteristic

Solubility: Insoluble in water, its sodium salt is the water-soluble, its organic solution has blue fluorescence.

Specification: 10-hydroxycamptothecin >98%

Sieve analysis: 100% through 80 mesh

Storage: Store in cool & dry place, Keep away from strong light and heat.

Shelf life: 24Months when properly stored.

Packing: Aluminum foil-bag and two plastic-bags inside

Functions:

10-hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). Is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC[2]and HL-60[3]cells. The purpose of this study is to investigate the proliferation-inhibiting and differentiation-inducing actions of HCPT on human hepatoma Hep G2 cells.