New data from a completed Phase 3 trial show Lilly’s Trulicity (dulaglutide) 1.5 mg plus a sulfonylurea was significantly more effective than a sulfonylurea alone in lowering haemoglobin A1c (A1C) from baseline after 24 weeks of treatment.
Trulicity is a once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist for the treatment of type 2 diabetes.
“For patients who cannot tolerate or have contraindications to metformin, a sulfonylurea is often prescribed as first-line therapy for type 2 diabetes,” said Kathleen Dungan, M.D., endocrinologist, associate professor, The Ohio State University Wexner Medical Centre. “This study affirms that Trulicity is efficacious and well-tolerated as an add-on to sulfonylurea therapy, which can help prescribers make treatment decisions for their individual patients.”
In addition to superior A1C reduction from baseline, significantly more patients treated with Trulicity 1.5 mg plus sulfonylurea achieved an A1C of less than 7 percent (55.3 percent) compared to sulfonylurea with placebo (18.9 percent). Also, Trulicity plus a sulfonylurea significantly reduced fasting serum glucose levels compared to sulfonylurea with placebo (-30.60 mg/dL vs. +2.93 mg/dL).
