Targeted therapies have played an increasingly important role in tumor treatment in recent years. I’d like to introduce in detail an “upstart”—CDK 4/6 inhibitors in the breast cancer therapeutic area today. Pfizer’s palbociclib, Novartis’ ribociclib, and Eli Lilly’s abemaciclib have been approved for marketing and formed a situation of tripartite confrontation, wherein, the global sales of Pfizer’s palbociclib accounted for 89% of the CDK 4/6 inhibitor market in 2018 upon its first-mover advantage, however, the annual growth of palbociclib has gradually declined in recent years, and many enterprises have laid out the area. Therefore, it is still unknown as to whether which will dominate the CDK 4/6 inhibitor market in the future.